Finally in the ‘Mental Health’ System – LONG, HARD, ROAD AHEAD – I SEE HOPE!

Living with severe pain and severe mental health issues. My first blog for a while here, and I didn’t really want to do it either, but as we reach out, others reach back. It started for me, the journey of pain and mental health about 15 years ago. I had issues from Childhood that haunted me when I was signed off from being allowed to Work all these years ago. The cycle of pain and mental health is a tricky one. The medications I am now on are less, but better and just as powerful. Today I am TRYING to start being a sit-down DJ again through the Stafford Center below and also singing lessons to FINALLY TRY and sit on a stage and create moment of ‘Music’. Always I have this view that Sport, Politics, Religion, and the worse one, MONEY just divide us all, well most of us. For me, just me, Music is my God, it speaks to me, and it listens back. I need a stage, I need to be part of something for myself. I spent too long doing things for others. I lost most of my Family because of these issues, but Family who mock, don’t understand, make things worse, are they worth having? For me no, but we all have our own ways. What I do know is, when we get ill in ANY way and it effects us badly, people walk away. FAMILY say things like “I am not getting involved”, but who am I to talk, I walked away from the emotion of HATE I had and still do have. Family just unable to hear us speak and just say ‘Nice one’ then change the subject. I am fighting for myself this time. I have lost, BUT SO HAVE YOU. We ALL have a something, we all have things holding us back, making us dread moving forward. We all lose, we all hurt, we are all just human. We live in a selfish money chasing brainwashed World. So I am doing this for me, but I have two little Girls here, my Daughters. All I am trying to do is make sure they are like their brothers, I hope they grow up and find HAPPY, without money, hate, anger, struggle. And understand who they want in their lives as they grow. They are only 7 and 8 years old, but my Job is to gently and over time tell them ‘It is your life, you make the choices, and to NEVER allow another to dictate to them in any way possible’, it really is that simple. Like you I am surrounded by people not in control, and these people work, have money, CHOOSE the life they lead, and are owned by emotions and the emotions of others. I dislike these people because of the impact they have on my Girls. Never hate, I say it below always. Just typing to TRY and connect. This took me like 3 hours today 😀 I hope 2 people read it.

BE KIND TO YOURSELF!

DON’T ALLOW OTHERS TO STEAL YOUR LIFE, THOUGHTS OR EMOTIONS.

Be yourself and NEVER compromise this. When you do, you give your control to others.

For now…

..Below is the system of help I am in just now. I will be adding a pain-team back to this list shortly

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This was my first HELP about 12 years ago:

@Dr_A_Dobbin – On Twitter

https://www.facebook.com/PositiveMentalTraining/

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The River Center is for people suicidal, depressed, just lost in life:

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I am now here. The possibility to be a DJ again, AND TO SING (Is the plan)

https://www.facebook.com/TheStaffordCentre

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MORE LOVE, LESS HATE

blogger-for-peace-van-2

BLOGGERS FOR PEACE AND SANITY

THIS DOES NOT REPRESENT ALL DISABLED PEOPLE

THIS DOES NOT REPRESENT ALL DISABLED PEOPLE

Shaun Gibson Twitter: @ShaunyScot
Skype Username: shaunyg1973
Shaun Celtic FC Twitter: @ShaunyCeltic

THE ABOVE IMAGE NEEDS CHANGED TO THIS - THIS REPRESENTS 'BETTER' FOR SOCIETY TO JUDGE

THE ABOVE IMAGE NEEDS CHANGED TO THIS – THIS REPRESENTS ‘BETTER’ FOR SOCIETY TO JUDGE

 

 

 

Cancer-killing stem cells engineered in lab

Brain tumours are often solid and hard to reach so stem cells are an effective way of targeting them

Brain tumours are often solid and hard to reach so stem cells are an effective way of targeting them

Scientists from Harvard Medical School have discovered a way of turning stem cells into killing machines to fight brain cancer.

There may soon be a new way to use stem cells in the fight against brain cancer. A team has created a way to genetically engineer stem cells so that they can produce and secrete tumor-killing toxins that eradicate cancer cells remaining in mouse brains after their main tumor has been removed.

The stem cells are placed at the site encapsulated in a biodegradable gel. This method solves the delivery issue that probably led to the failure of recent clinical trials aimed at delivering purified cancer-killing toxins into patients’ brains.  Cytotoxins are deadly to all cells, but since the late 1990s, researchers have been able to tag toxins in such a way that they only enter cancer cells with specific surface molecules; making it possible to get a toxin into a cancer cell without posing a risk to normal cells. Once inside of a cell, the toxin disrupts the cell’s ability to make proteins and, within days, the cell starts to die.

Encapsulated toxin-producing stem cells (in blue) help kill brain tumor cells in the tumor resection cavity (in green). Credit: Khalid Shah, MS, PhD

“Cancer-killing toxins have been used with great success in a variety of blood cancers, but they don’t work as well in solid tumors because the cancers aren’t as accessible and the toxins have a short half-life,” said Harvard neuroscientist Khalid Shah, MS, PhD, who directs the Molecular Neurotherapy and Imaging Lab at Massachusetts General Hospital and Harvard Medical School. “A few years ago we recognized that stem cells could be used to continuously deliver these therapeutic toxins to tumors in the brain, but first we needed to genetically engineer stem cells that could resist being killed themselves by the toxins. Now, we have toxin-resistant stem cells that can make and release cancer-killing drugs.”

Shah’s stem cells escape this fate because they are made with a mutation that doesn’t allow the toxin to act inside the cell. The toxin-resistant stem cells also have an extra bit of genetic code that allows them to make and secrete the toxins. Any cancer cells that these toxins encounter do not have this natural defense and therefore die. Shah and his team induced toxin resistance in human neural stem cells and subsequently engineered them to produce targeted toxins.

“We tested these stem cells in a clinically relevant mouse model of brain cancer, where you resect the tumors and then implant the stem cells encapsulated in a gel into the resection cavity,” Shah said. “After doing all of the molecular analysis and imaging to track the inhibition of protein synthesis within brain tumors, we do see the toxins kill the cancer cells and eventually prolonging the survival in animal models of resected brain tumors.”

Shah next plans to rationally combine the toxin-secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults. Shah predicts that he will bring these therapies into clinical trials within the next five years.

http://www.bbc.co.uk/news/health-29756238#?utm_source=twitterfeed&utm_medium=twitter

http://www.popsci.com/article/science/injecting-engineered-stem-cells-brain-may-effectively-treat-tumors

http://hsci.harvard.edu/news/scientists-engineer-toxin-secreting-stem-cells-treat-brain-tumors

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Nurses call for more training in Ebola fight

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US Nurses are not happy, rightly so!

AUSTIN — Most health care workers here have long known about the Ebola virus, but never had to deal with it. In that sense, “Ebola is new to us,” said Cindy Zolnierek, executive director of the Texas Nurses Association. Now one of their own is sickened with Ebola. While Zolnierek said Nina Pham is “in our thoughts,” she added that many nurses also are thinking of their own health. “They are concerned… and they should be,” said Stacey Cropley, director of Practice at the Texas Nurses Association. That organization — which represents more than 7,000 Texas nurses — is calling for more training, and is urging health care workers to speak up to hospital management whenever they have questions or concerns about safety. “The only way you do that is to get people comfortable with being transparent,” said Joyce Batcheller, nurse and president of CNO Solutions, a health care executive recruitment company.

CBS Evening News

She said fostering the kind of transparency that might help make the Ebola response better starts by investigating when things go wrong, but avoiding the blame game. Many health care workers weren’t happy with recent comments by Dr. Tom Frieden, director of the U.S. Centers for Disease Control and Protection, that the Dallas nurse contracted Ebola after a “breach in protocol.” “When you say there was a ‘breach,’ that sounds like the nurse thought, ‘Let me mess this up,’ and that’s not true,” Batcheller said. Pham, 26, became infected while treating Thomas Eric Duncan, the first Ebola patient to die in the USA. Pham is the first person known to contract the disease in the USA. She issued a brief statement through Texas Health Presbyterian Hospital saying she is “doing well” and thanking the medical team providing her care.

“I’m doing well and want to thank everyone for their kind wishes and prayers,” the statement said. “I am blessed by the support of family and friends and am blessed to be cared for by the best team of doctors and nurses in the world here.” Frieden said Tuesday that officials have thus far failed to determine how Pham contracted the virus during treatment of Duncan. Officials with the Texas Nurses Association are speaking out, hoping to give voice to the professionals who work silently inside the hazmat suits doing the hard, stressful and often dirty work. Those who have come into contact with Ebola patients at Texas Health Presbyterian Hospital in Dallas have been required to shower after each patient interaction. Their colleagues have been banding together to make that precautionary procedure a little less of a chore. “The other nurses are buying them high-end bath products, so there is that kind of caretaking that is really wonderful to see,” Zolnierek said.

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